A Trust Model Based on Service Classification in Mobile Services

Internet of Things (IoT) and B3G/4G communication are promoting the pervasive mobile services with its advanced features. However, security problems are also baffled the development. This paper proposes a trust model to protect the user's security. The billing or trust operator works as an agent to provide a trust authentication for all the service providers. The services are classified by sensitive value calculation. With the value, the user's trustiness for corresponding service can be obtained. For decision, three trust regions are divided, which is referred to three ranks: high, medium and low. The trust region tells the customer, with his calculated trust value, which rank he has got and which authentication methods should be used for access. Authentication history and penalty are also involved with reasons.Comment: IEEE/ACM Internet of Things Symposium (IOTS), in conjunction with GreenCom 2010, IEEE, Hangzhou, China, December 18-20, 201

Caractérisation électrique et modélisation du transport dans matériaux et dispositifs SOI avancés

This thesis is dedicated to the electrical characterization and transport modeling in advanced SOImaterials and devices for ultimate micro-nano-electronics. SOI technology is an efficient solution tothe technical challenges facing further downscaling and integration. Our goal was to developappropriate characterization methods and determine the key parameters. Firstly, the conventionalpseudo-MOSFET characterization was extended to heavily-doped SOI wafers and an adapted modelfor parameters extraction was proposed. We developed a nondestructive electrical method to estimatethe quality of bonding interface in metal-bonded wafers for 3D integration. In ultra-thin fully-depletedSOI MOSFETs, we evidenced the parasitic bipolar effect induced by band-to-band tunneling, andproposed new methods to extract the bipolar gain. We investigated multiple-gate transistors byfocusing on the coupling effect in inversion-mode vertical double-gate SOI FinFETs. An analyticalmodel was proposed and subsequently adapted to the full depletion region of junctionless SOI FinFETs.We also proposed a compact model of carrier profile and adequate parameter extraction techniques forjunctionless nanowires.Cette thèse est consacrée à la caractérisation et la modélisation du transport électronique dans des matériaux et dispositifs SOI avancés pour la microélectronique. Tous les matériaux innovants étudiés(ex: SOI fortement dopé, plaques obtenues par collage etc.) et les dispositifs SOI sont des solutions possibles aux défis technologiques liés à la réduction de taille et à l'intégration. Dans ce contexte,l'extraction des paramètres électriques clés, comme la mobilité, la tension de seuil et les courants de fuite est importante. Tout d'abord, la caractérisation classique pseudo-MOSFET a été étendue aux plaques SOI fortement dopées et un modèle adapté pour l'extraction de paramètres a été proposé. Nous avons également développé une méthode électrique pour estimer la qualité de l'interface de collage pour des plaquettes métalliques. Nous avons montré l'effet bipolaire parasite dans des MOSFET SOI totalement désertés. Il est induit par l’effet tunnel bande-à-bande et peut être entièrement supprimé par une polarisation arrière. Sur cette base, une nouvelle méthode a été développée pour extraire le gain bipolaire. Enfin, nous avons étudié l'effet de couplage dans le FinFET SOI double grille, en mode d’inversion. Un modèle analytique a été proposé et a été ensuite adapté aux FinFETs sans jonction(junctionless). Nous avons mis au point un modèle compact pour le profil des porteurs et des techniques d’extraction de paramètres

Anderson acceleration for geometry optimization and physics simulation

Many computer graphics problems require computing geometric shapes subject to certain constraints. This often results in non-linear and non-convex optimization problems with globally coupled variables, which pose great challenge for interactive applications. Local-global solvers developed in recent years can quickly compute an approximate solution to such problems, making them an attractive choice for applications that prioritize efficiency over accuracy. However, these solvers suffer from lower convergence rate, and may take a long time to compute an accurate result. In this paper, we propose a simple and effective technique to accelerate the convergence of such solvers. By treating each local-global step as a fixed-point iteration, we apply Anderson acceleration, a well-established technique for fixed-point solvers, to speed up the convergence of a local-global solver. To address the stability issue of classical Anderson acceleration, we propose a simple strategy to guarantee the decrease of target energy and ensure its global convergence. In addition, we analyze the connection between Anderson acceleration and quasi-Newton methods, and show that the canonical choice of its mixing parameter is suitable for accelerating local-global solvers. Moreover, our technique is effective beyond classical local-global solvers, and can be applied to iterative methods with a common structure. We evaluate the performance of our technique on a variety of geometry optimization and physics simulation problems. Our approach significantly reduces the number of iterations required to compute an accurate result, with only a slight increase of computational cost per iteration. Its simplicity and effectiveness makes it a promising tool for accelerating existing algorithms as well as designing efficient new algorithms

Fulvestrant, an estrogen receptor inhibitor, relieves postoperative hemorrhoid edema via up-regulation of miR- 424-5p

Purpose: To investigate estrogen receptor (ER) expression in postoperative hemorrhoid edema tissues, and the likely mechanism involved in fulvestrant-mediated reduction of postoperative hemorrhoid edema.Methods: One hundred and eighty-five patients admitted to Jinshan Hospital of Fudan University, Shanghai who accepted hemorrhoidectomy were enrolled in this study. Primary cells were extracted from the anal margin tissues of patients for the determination of changes in ERα and vascular endothelial growth factor (VEGF). In vitro cellular experiments were performed in primary vascular endothelial cells to verify whether ER promoted postoperative perianal edema via the miR-424-5p estrogen receptor α gene (ESR1) axis. The cells were exposed to Fulvestrant, estradiol, and miR-424-5p mimic. Changes in expressions of ERα and VEGF were determined.Results: Fourteen patients (7.57 %), comprising 2 males (2.60 %) and 12 females (11.1 %), developedpostoperative anal margin edema. There was a significant difference in the incidence of postoperative anal edema between males and females (p < 0.05). Both immunohistochemistry and immunoblotting revealed markedly higher ERα levels in postoperative anal edema tissues than in preoperative tissues (p < 0.05). Moreover, ERα level was regulated by estradiol, and miR-424-5p targeted the estrogen receptor α gene (ESR1).Conclusion: Estradiol inhibits miR-424-5p through ERα in perianal tissues after hemorrhoid surgery. It increases VEGF and promotes perianal edema. However, fulvestrant inhibits ERα, thereby reducing VEGF expression and mitigating postoperative hemorrhoid edema, and therefore, has potential application for the management of postoperative hemorrhoid edema

Preparation of a Peptide-Modified Electrode for Capture and Voltammetric Determination of Endotoxin

Endotoxin is the major structural constituent of the outer membrane of Gram-negative bacteria, which is a great threat to human health. Herein, a sensitive electrochemical biosensor for the detection of endotoxin is established by recording the voltammetric responses of the peptide-modified electrode. The utilized peptide has a high affinity for the target endotoxin, which ensures the high selectivity of this method. After the capture of endotoxin on the electrode surface, a negatively charged layer is formed, and the electron-transfer process is significantly hindered because of the increased steric hindrance and the electrostatic repulsion. The declined electrochemical signal could be used to indicate the concentration of endotoxin. This method is simple but effective, which requires limited reagents. Another highlight of this method is its user-friendly operation. Moreover, its applicability in human blood plasma promises its great potential utility in the near future

Converting metal-organic framework particles from hydrophilic to hydrophobic by an interfacial assembling route

Here we propose to modify the hydrophilicity of metal-organic framework (MOF) particles by an interfacial assembling route, which is based on the surface-active nature of MOF particles. It was found that hydrophilic UiO-66-NH₂ particles can be converted to hydrophobic particles through an oil-water interfacial assembling route. The underlying mechanism for the conversion of UiO-66-NH₂ was investigated by X-ray photoelectron spectroscopy and FT-IR spectroscopy. It was revealed that the close assembly of UiO-66-NH₂ particles at the oil-water interface strengthens the coordination between organic ligands and metal ions, which results in a decrease in the proportion of hydrophilic groups on UiO-66-NH₂ particle surfaces. Hydrophobic UiO-66-NH₂ particles show improved adsorption capacity for dyes in organic solvents compared with pristine UiO-66-NH₂ particles. It is expected that the interfacial assembling route can be applied to the synthesis of different kinds of MOF materials with tunable hydrophilicity or hydrophobicity required for diverse applications

Effects of Impeller Diameter on High-Speed Rescue Pump

Impeller diameter is a crucial design parameter of high-speed rescue pumps because it affects the performance and inner flow characteristics of these pumps. In this study, a pump with an impeller diameter of 248 mm was modeled and its performance was tested. Numerical simulations were conducted under steady and unsteady states, in which the sizes of the impeller diameters were designated as 248 mm (original), 235.6 mm (5% trimmed), 223.2 mm (10% trimmed), and 210.8 mm (15% trimmed). ANSYS software was used to test the shear stress transport (SST k-ω) of the four models, and results agreed well with experimental data. Diameter size affected impeller characteristics in both steady and unsteady states. Subsequently, the differences in performance, hydraulic loss, pressure pulsation, and radial force of the impellers were evaluated. In the performance test, the head and efficiency of the pump decreased as impeller diameter was reduced. The result trends are in accordance with the trim law within the acceptable error range. In terms of hydraulic loss, the impeller and diffuser vane components presented opposite trends with flow rate increase. Finally, in terms of pressure pulsation and radial force, the amplitude diminished while periodicity improved as impeller diameter decreased

Two-dimensional atomic-scale ultrathin lateral heterostructures

Ultrathin lateral heterostructures of monolayer MoS2 and WS2 have successfully been realized with the metal-organic chemical vapor deposition method. Atomic-resolution HAADF-STEM observations have revealed that the junction widths of lateral heterostructures range from several nanometers to single-atom thickness, the thinnest heterojunction in theory. The interfaces are atomically flat with minimal mixing between MoS2 and WS2, originating from rapid and abrupt switching of the source supply. Due to one-dimensional interfaces and broken rotational symmetry, the resulting ultrathin lateral heterostructures, 1~2 mixed-dimensional structures, can show emergent optical/electronic properties. The MOCVD growth developed in this work allows us to access various ultrathin lateral heterostructures, leading to future exploration of their emergent properties absent in each component alone

Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer

Esophageal cancer (EC) is an aggressive form of cancer, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) as two predominant histological subtypes. Accumulating evidence supports the existence of cancer stem cells (CSCs) able to initiate and maintain EAC or ESCC. In this review, we aim to collect the current evidence on CSCs in esophageal cancer, including the biomarkers/characterization strategies of CSCs, heterogeneity of CSCs, and the key signaling pathways (Wnt/β-catenin, Notch, Hedgehog, YAP, JAK/STAT3) in modulating CSCs during esophageal cancer progression. Exploring the molecular mechanisms of therapy resistance in EC highlights DNA damage response (DDR), metabolic reprogramming, epithelial mesenchymal transition (EMT), and the role of the crosstalk of CSCs and their niche in the tumor progression. According to these molecular findings, potential therapeutic implications of targeting esophageal CSCs may provide novel strategies for the clinical management of esophageal cancer